Download e-book for kindle: Basic Aspects of Catechol-O-Methyltransferase and the by Erkki Nissinen

By Erkki Nissinen

quantity ninety five of International overview of Neurobiology makes a speciality of Catechol-O-methyltransferase inhibition, and its scientific software relating to Parkinson’s ailment. Chapters disguise COMT gene and proteins, L-dopa therapy in Parkinson’s illness, the newest examine on COMT inhibitors and their medical functions, in addition to destiny clients for his or her use.

  • Up-to-date precis of biochemistry and pharmacology of COMT and its inhibitors
  • Preclinical types in COMT inhibitor devlopment
  • Transgenic COMT mice – most up-to-date info summarized
  • Chemistry of COMT inhibitors and their layout with molecular modelling
  • COMT gene and its legislation and relation to dopamine comparable diseases
  • Role of cofactor SAM legislation in terms of homocysteine
  • Nonclinical and scientific protection of COMT inhibitors summarized
  • Future clients of COMT inhibitors in Parkinson’s disease

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Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors: 95 (International Review of Neurobiology) by Erkki Nissinen


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