Download e-book for iPad: Biotransformation and Metabolite Elucidation of Xenobiotics: by Ala F. Nassar

By Ala F. Nassar

The aim of this booklet is to enhance the readers' wisdom of metabolite elucidation in drug metabolism through exposing them to intensive assurance of the biotransformation of xenobiotics, options for choosing and characterizing metabolites, FDA directions, and case reports on how one can enhance the decision-making technique in structural amendment of drug applicants to lessen toxicity.

The publication involves eight chapters; it first presents an advent on biotransformation of xenobiotics, after which offers glossy techniques and techniques for facing metabolite characterization, utilizing instruments reminiscent of LC-MS, H-D alternate, solid isotopes LC-MS-NMR, and radiolabeled compounds. additionally, ideas for facing reactive intermediates in drug discovery and improvement are provided in addition to case reports on bettering the decision-making approach within the structural amendment of drug applicants. The final bankruptcy discusses the regulatory views of safeguard checking out of drug metabolites and why, how, and while to check their safety.

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Biotransformation and Metabolite Elucidation of Xenobiotics: Characterization and Identification by Ala F. Nassar


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