New PDF release: Antisense Drug Technology: Principles, Strategies, and

By Stanley T. Crooke

broadly revised and up to date, Antisense Drug know-how: ideas, techniques, and purposes, moment Edition displays the logarithmic development made long ago 4 years of oligonucleotide-based cures, and, particularly, antisense therapeutics and study. studying classes realized from the scientific trials of first new release medicinal drugs, the e-book evaluates the expertise as an entire and gives new instructions and avenues of study and improvement.

Divided into 5 components, the publication starts with an intensive creation to the mechanism of antisense drug motion together with the RNase H mechanism, small RNA silencing pathways, and the capability therapeutics of splice switching oligonucleotides. top researchers exhibit the fundamentals of oligonucleotide therapeutics partly via delineating medicinal chemistry, pharmacokinetics, and supply routes akin to liposomal formulations for nucleic acid delivery.  half 3 information hybridization dependent medications and considers the dramatic advances represented by way of 2’ methoxyethyl chimeric antisense inhibitors and duplex RNA medications. different chemical sessions of substances and mechanisms of motion are defined partly 4 with extra discussions on enhancing the second one iteration antisense medications. the ultimate half delves deeply into healing purposes. Contributing authors learn the potential for antisense medicines for the relief of cardiovascular ailments, metabolic illnesses, inflammatory illnesses, melanoma, neurological problems, and immune modulation.

Presenting a hugely specified, lucid dialogue of the outstanding advances within the box, Antisense Drug expertise: rules, recommendations, and purposes, moment Edition presents the platform for researchers to proceed to aggressively pursue the nice chance represented by way of this fascinating technology.

--This textual content refers back to the Hardcover edition.

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Antisense Drug Technology: Principles, Strategies, and Applications: Principles, Strategies and Applications by Stanley T. Crooke

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